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David Rosania's avatar

Thank you for sharing. A couple of comments from a fellow skeptic.

1. The vast majority of diet studies are observational and hugely subject to confounding. Even the RCTs are essentially impossible to blind - either the authors or the subjects. So IMO the entire body of research on diet and disease is questionable at best. To the extent that any of it might be valid, the Mediterranean Diet seems to have the most support. And this diet is pretty far from full-fat, or heavy on dairy, or "slathering in butter."

2. Athletic performance for most people benefits from reduced fat and higher carb intake. There are a lot of RCTs in this arena. So if you want to do something that actually has strong evidence of benefit - exercise - maybe keep the fat low. There are apparently some athletic outliers who thrive on high-fat diets. This is not me or most exercisers. Eating a bagel or a banana and going for a run, sure. An omelet or a plate of bacon or sausage, not so much.

3. CAC scores. Your friend and colleague, and brilliant analyst of research and clinical practice, John Mandrola, is not a fan, especially for asymptomatic people. He has addressed this topic several times over the years, and his argument is pretty solid.

https://www.sensible-med.com/p/coronary-artery-calcium-trial-fails

https://www.aafp.org/pubs/afp/issues/2019/1215/p734.html

We should all exercise, control weight and BP, minimize lipids, not smoke, and treat disease, regardless of our metabolic and health parameters. But personalized medicine with full-body scans and batteries of tests, continue to show no benefit in any study I have seen. Including CAC scores.

What am I getting wrong?

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Dr. Ashori MD's avatar

Many have an easier time giving up meat but eggs and dairy are tough. So it stands to reason that we'd hope for the saturated fats from dairy to somehow be immune to the same biochemical processes. Yet dairy consumption tends to cluster with other lifestyle habits that vary widely between individuals, making it hard to isolate the true cardiovascular impact of dairy through observational studies alone.

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